diff --git a/package/pkg-python.mk b/package/pkg-python.mk
index be1ce071df..4ded4fde83 100644
--- a/package/pkg-python.mk
+++ b/package/pkg-python.mk
@@ -27,9 +27,7 @@ endef
 # Target distutils-based packages
 PKG_PYTHON_DISTUTILS_ENV = \
 	PATH=$(BR_PATH) \
-	CC="$(TARGET_CC)" \
-	CFLAGS="$(TARGET_CFLAGS)" \
-	LDFLAGS="$(TARGET_LDFLAGS)" \
+	$(TARGET_CONFIGURE_OPTS) \
 	LDSHARED="$(TARGET_CROSS)gcc -shared" \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
 	PYTHONNOUSERSITE=1 \
@@ -52,7 +50,8 @@ PKG_PYTHON_DISTUTILS_INSTALL_STAGING_OPTS = \
 # Host distutils-based packages
 HOST_PKG_PYTHON_DISTUTILS_ENV = \
 	PATH=$(BR_PATH) \
-	PYTHONNOUSERSITE=1
+	PYTHONNOUSERSITE=1 \
+	$(HOST_CONFIGURE_OPTS)
 
 HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR)
@@ -61,6 +60,7 @@ HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS = \
 PKG_PYTHON_SETUPTOOLS_ENV = \
 	_PYTHON_SYSCONFIGDATA_NAME="$(PKG_PYTHON_SYSCONFIGDATA_NAME)" \
 	PATH=$(BR_PATH) \
+	$(TARGET_CONFIGURE_OPTS) \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
 	PYTHONNOUSERSITE=1 \
 	_python_sysroot=$(STAGING_DIR) \
@@ -82,7 +82,8 @@ PKG_PYTHON_SETUPTOOLS_INSTALL_STAGING_OPTS = \
 # Host setuptools-based packages
 HOST_PKG_PYTHON_SETUPTOOLS_ENV = \
 	PATH=$(BR_PATH) \
-	PYTHONNOUSERSITE=1
+	PYTHONNOUSERSITE=1 \
+	$(HOST_CONFIGURE_OPTS)
 
 HOST_PKG_PYTHON_SETUPTOOLS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR) \