diff --git a/package/gnuradio/Config.in b/package/gnuradio/Config.in
index 6d0669779f..80f6a1c535 100644
--- a/package/gnuradio/Config.in
+++ b/package/gnuradio/Config.in
@@ -66,11 +66,15 @@ config BR2_PACKAGE_GNURADIO_PYTHON
 	bool "python support"
 	depends on BR2_PACKAGE_PYTHON
 	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
 	select BR2_PACKAGE_BOOST_PYTHON
 	select BR2_PACKAGE_PYTHON_NUMPY # runtime
 	help
 	  Enable python component
 
+comment "python support needs glibc or musl"
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL)
+
 config BR2_PACKAGE_GNURADIO_UTILS
 	bool "gr-utils support"
 	depends on BR2_PACKAGE_GNURADIO_PYTHON
diff --git a/package/opencv3/Config.in b/package/opencv3/Config.in
index 3a6ff8e80c..cf7763d4ae 100644
--- a/package/opencv3/Config.in
+++ b/package/opencv3/Config.in
@@ -158,11 +158,15 @@ config BR2_PACKAGE_OPENCV3_LIB_PYTHON
 	bool "python"
 	depends on BR2_PACKAGE_PYTHON || BR2_PACKAGE_PYTHON3
 	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
 	select BR2_PACKAGE_PYTHON_NUMPY
 	help
 	  Include opencv_python module into the OpenCV build.  No
 	  python example is installed.
 
+comment "python support needs glibc or musl"
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL)
+
 config BR2_PACKAGE_OPENCV3_LIB_SHAPE
 	bool "shape"
 	# opencv_core dependency is already enabled
diff --git a/package/piglit/Config.in b/package/piglit/Config.in
index 7a16c94284..736fd95d71 100644
--- a/package/piglit/Config.in
+++ b/package/piglit/Config.in
@@ -6,6 +6,7 @@ config BR2_PACKAGE_PIGLIT
 		BR2_PACKAGE_WAFFLE_SUPPORTS_WAYLAND || \
 		BR2_PACKAGE_WAFFLE_SUPPORTS_X11_EGL || \
 		BR2_PACKAGE_WAFFLE_SUPPORTS_GBM
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
 	select BR2_PACKAGE_LIBDRM if BR2_PACKAGE_HAS_LIBGL
 	select BR2_PACKAGE_LIBPNG
 	select BR2_PACKAGE_LIBXKBCOMMON if BR2_PACKAGE_WAYLAND
@@ -29,3 +30,6 @@ config BR2_PACKAGE_PIGLIT
 	  implementations.
 
 	  https://piglit.freedesktop.org
+
+comment "piglit needs glibc or musl"
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL)
diff --git a/package/python-matplotlib/Config.in b/package/python-matplotlib/Config.in
index 14f43568f3..07160affd0 100644
--- a/package/python-matplotlib/Config.in
+++ b/package/python-matplotlib/Config.in
@@ -3,6 +3,7 @@ config BR2_PACKAGE_PYTHON_MATPLOTLIB
 	depends on BR2_INSTALL_LIBSTDCPP
 	depends on BR2_PACKAGE_PYTHON3
 	depends on BR2_PACKAGE_PYTHON_NUMPY_ARCH_SUPPORTS
+	depends on BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL # python-numpy
 	select BR2_PACKAGE_FREETYPE # runtime
 	select BR2_PACKAGE_LIBPNG # runtime
 	select BR2_PACKAGE_PYTHON_CYCLER
@@ -23,3 +24,6 @@ config BR2_PACKAGE_PYTHON_MATPLOTLIB
 
 comment "python-matplotlib needs a toolchain w/ C++"
 	depends on !BR2_INSTALL_LIBSTDCPP
+
+comment "python-matplotlib needs glibc or musl"
+	depends on !(BR2_TOOLCHAIN_USES_GLIBC || BR2_TOOLCHAIN_USES_MUSL)