diff --git a/package/pkg-python.mk b/package/pkg-python.mk
index fb124e1dd3..2418f5dfa4 100644
--- a/package/pkg-python.mk
+++ b/package/pkg-python.mk
@@ -32,6 +32,7 @@ PKG_PYTHON_DISTUTILS_ENV = \
 	LDFLAGS="$(TARGET_LDFLAGS)" \
 	LDSHARED="$(TARGET_CROSS)gcc -shared" \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
+	PYTHONNOUSERSITE=1 \
 	_PYTHON_SYSCONFIGDATA_NAME="$(PKG_PYTHON_SYSCONFIGDATA_NAME)" \
 	_python_sysroot=$(STAGING_DIR) \
 	_python_prefix=/usr \
@@ -48,7 +49,8 @@ PKG_PYTHON_DISTUTILS_INSTALL_STAGING_OPTS = \
 
 # Host distutils-based packages
 HOST_PKG_PYTHON_DISTUTILS_ENV = \
-	PATH=$(BR_PATH)
+	PATH=$(BR_PATH) \
+	PYTHONNOUSERSITE=1
 
 HOST_PKG_PYTHON_DISTUTILS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR)/usr
@@ -58,6 +60,7 @@ PKG_PYTHON_SETUPTOOLS_ENV = \
 	_PYTHON_SYSCONFIGDATA_NAME="$(PKG_PYTHON_SYSCONFIGDATA_NAME)" \
 	PATH=$(BR_PATH) \
 	PYTHONPATH="$(if $(BR2_PACKAGE_PYTHON3),$(PYTHON3_PATH),$(PYTHON_PATH))" \
+	PYTHONNOUSERSITE=1 \
 	_python_sysroot=$(STAGING_DIR) \
 	_python_prefix=/usr \
 	_python_exec_prefix=/usr
@@ -76,7 +79,8 @@ PKG_PYTHON_SETUPTOOLS_INSTALL_STAGING_OPTS = \
 
 # Host setuptools-based packages
 HOST_PKG_PYTHON_SETUPTOOLS_ENV = \
-	PATH=$(BR_PATH)
+	PATH=$(BR_PATH) \
+	PYTHONNOUSERSITE=1
 
 HOST_PKG_PYTHON_SETUPTOOLS_INSTALL_OPTS = \
 	--prefix=$(HOST_DIR)/usr