diff --git a/package/python-subprocess32/Config.in b/package/python-subprocess32/Config.in
index a936b064b0..d7fe84f1e6 100644
--- a/package/python-subprocess32/Config.in
+++ b/package/python-subprocess32/Config.in
@@ -1,8 +1,13 @@
 config BR2_PACKAGE_PYTHON_SUBPROCESS32
 	bool "python-subprocess32"
 	depends on BR2_PACKAGE_PYTHON
+	depends on BR2_TOOLCHAIN_HEADERS_AT_LEAST_3_10 || !BR2_MIPS_NABI64
 	help
 	  A backport of the Python 3 subprocess module for use
 	  on Python 2.
 
 	  https://github.com/google/python-subprocess32
+
+comment "python-subprocess32 needs a toolchain w/ headers >= 3.10 on MIPS N64"
+	depends on BR2_MIPS_NABI64
+	depends on !BR2_TOOLCHAIN_HEADERS_AT_LEAST_3_10