diff --git a/include/net/netfilter/nf_nat.h b/include/net/netfilter/nf_nat.h
index bd8eea720f2e..ad14a799fd2e 100644
--- a/include/net/netfilter/nf_nat.h
+++ b/include/net/netfilter/nf_nat.h
@@ -68,4 +68,19 @@ static inline struct nf_conn_nat *nfct_nat(const struct nf_conn *ct)
 #endif
 }
 
+static inline bool nf_nat_oif_changed(unsigned int hooknum,
+				      enum ip_conntrack_info ctinfo,
+				      struct nf_conn_nat *nat,
+				      const struct net_device *out)
+{
+#if IS_ENABLED(CONFIG_IP_NF_TARGET_MASQUERADE) || \
+    IS_ENABLED(CONFIG_IP6_NF_TARGET_MASQUERADE)
+	return nat->masq_index && hooknum == NF_INET_POST_ROUTING &&
+	       CTINFO2DIR(ctinfo) == IP_CT_DIR_ORIGINAL &&
+	       nat->masq_index != out->ifindex;
+#else
+	return false;
+#endif
+}
+
 #endif
diff --git a/net/ipv4/netfilter/iptable_nat.c b/net/ipv4/netfilter/iptable_nat.c
index ac635a7b4416..da2c8a368f68 100644
--- a/net/ipv4/netfilter/iptable_nat.c
+++ b/net/ipv4/netfilter/iptable_nat.c
@@ -134,6 +134,10 @@ nf_nat_ipv4_fn(unsigned int hooknum,
 		/* ESTABLISHED */
 		NF_CT_ASSERT(ctinfo == IP_CT_ESTABLISHED ||
 			     ctinfo == IP_CT_ESTABLISHED_REPLY);
+		if (nf_nat_oif_changed(hooknum, ctinfo, nat, out)) {
+			nf_ct_kill_acct(ct, ctinfo, skb);
+			return NF_DROP;
+		}
 	}
 
 	return nf_nat_packet(ct, ctinfo, hooknum, skb);
diff --git a/net/ipv6/netfilter/ip6table_nat.c b/net/ipv6/netfilter/ip6table_nat.c
index fa84cf8ec6bc..6c8ae24b85eb 100644
--- a/net/ipv6/netfilter/ip6table_nat.c
+++ b/net/ipv6/netfilter/ip6table_nat.c
@@ -137,6 +137,10 @@ nf_nat_ipv6_fn(unsigned int hooknum,
 		/* ESTABLISHED */
 		NF_CT_ASSERT(ctinfo == IP_CT_ESTABLISHED ||
 			     ctinfo == IP_CT_ESTABLISHED_REPLY);
+		if (nf_nat_oif_changed(hooknum, ctinfo, nat, out)) {
+			nf_ct_kill_acct(ct, ctinfo, skb);
+			return NF_DROP;
+		}
 	}
 
 	return nf_nat_packet(ct, ctinfo, hooknum, skb);